Reactome | IL22 binds IL22RA1:JAK1 receptor complex

Schema > Reaction > Entries

IL22 binds IL22RA1:JAK1 receptor complex Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10479951
displayName	IL22 binds IL22RA1:JAK1 receptor complex
eventOf	[Pathway:R-SSC-8854691] Interleukin-20 family signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-448480] IL22 binds IL22RA1:JAK1 receptor complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-448460] IL22 [extracellular region] [Complex:R-SSC-8987233] IL22RA1:JAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL22 binds IL22RA1:JAK1 receptor complex IL22RA1 binds IL22
output	[Complex:R-SSC-448411] IL22:IL22RA1:JAK1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-8987043] IL22RA1 binds JAK1 - Sus scrofa [Reaction:R-SSC-448741] IL22RA2 binds IL22 - Sus scrofa
regulatedBy	[NegativeRegulation:10479952] Negative regulation by 'IL22RA2:IL22 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-448480
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8854691] Interleukin-20 family signaling
(precedingEvent)	[Reaction:R-SSC-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2
(inferredTo)	[Reaction:R-HSA-448480] IL22 binds IL22RA1:JAK1 receptor complex

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