Reactome | Receptor ACKR2 binds most inflammatory CC chemokines

Schema > Reaction > Entries

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10479098
displayName	Receptor ACKR2 binds most inflammatory CC chemokines
eventOf	[Pathway:R-SSC-380108] Chemokine receptors bind chemokines - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-443986] Receptor ACKR2 binds most inflammatory CC chemokines - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-443955] ACKR2 [plasma membrane] [DefinedSet:R-SSC-443962] CCBP2 ligands [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Receptor ACKR2 binds most inflammatory CC chemokines
output	[Complex:R-SSC-443988] ACKR2:CCBP2 ligands [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-443986
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-380108] Chemokine receptors bind chemokines
(inferredTo)	[Reaction:R-HSA-443986] Receptor ACKR2 binds most inflammatory CC chemokines

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