Reactome | Synthesis, secretion, and deacylation of Ghrelin

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Synthesis, secretion, and deacylation of Ghrelin Show undefined attributes

compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane [Compartment:1462052] secretory granule lumen [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557311
displayName	Synthesis, secretion, and deacylation of Ghrelin
eventOf	[Pathway:R-SSC-2980736] Peptide hormone metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19561] peptide hormone processing
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-422051] Cleavage of the signal peptide of Preproghrelin - Sus scrofa [Reaction:R-SSC-422104] Ghrelin O-acyltransferase octanoylates Proghrelin - Sus scrofa [Reaction:R-SSC-422017] Ghrelin O-acyltransferase decanoylates Proghrelin - Sus scrofa [Reaction:R-SSC-422021] PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin - Sus scrofa [BlackBoxEvent:R-SSC-422048] Acyl Ghrelin and C-Ghrelin are secreted - Sus scrofa [Reaction:R-SSC-9023619] Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin - Sus scrofa
inferredFrom	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis, secretion, and deacylation of Ghrelin
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-422085
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2980736] Peptide hormone metabolism
(inferredTo)	[Pathway:R-HSA-422085] Synthesis, secretion, and deacylation of Ghrelin