Reactome | GNE phosphorylates ManNAc to ManNAc-6-P

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GNE phosphorylates ManNAc to ManNAc-6-P Show undefined attributes

catalystActivity	[CatalystActivity:10509497] N-acylmannosamine kinase activity of GNE hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10509499
displayName	GNE phosphorylates ManNAc to ManNAc-6-P
eventOf	[Pathway:R-SSC-4085001] Sialic acid metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P - Sus scrofa
inferredFrom	[Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-4085214] ManNAc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GNE phosphorylates ManNAc to ManNAc-6-P aldehydo-N-acetyl-D-mannosamine + ATP => aldehydo-N-acetyl-D-mannosamine 6-phosphate + ADP + H(+)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-4085225] ManNAc-6-P [cytosol]
precedingEvent	[Reaction:R-SSC-4085021] GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-4085028
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-4085001] Sialic acid metabolism
(precedingEvent)	[Reaction:R-SSC-4084976] NANS converts ManNAc-6-P to Neu5Ac-9-P
(inferredTo)	[Reaction:R-HSA-4085028] GNE phosphorylates ManNAc to ManNAc-6-P

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