Reactome | LARG activation by G alpha 12/13

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LARG activation by G alpha 12/13 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10475318
displayName	LARG activation by G alpha 12/13
eventOf	[Pathway:R-SSC-416482] G alpha (12/13) signalling events - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-398185] LARG binds plexin B1 - Sus scrofa [Reaction:R-SSC-419166] GEFs activate RhoA,B,C - Sus scrofa
inferredFrom	[Reaction:R-HSA-398184] LARG activation by G alpha 12/13 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-416560] ARHGEF12 [cytosol] [DefinedSet:R-SSC-418572] G-protein alpha (12/13):GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	LARG activation by G alpha 12/13
output	[Complex:R-SSC-398145] G-protein alpha (12/13):LARG [plasma membrane]
precedingEvent	[Reaction:R-SSC-380073] Liganded Gi-activating GPCR acts as a GEF for Gi - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-398184
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-416482] G alpha (12/13) signalling events
(precedingEvent)	[Reaction:R-SSC-398185] LARG binds plexin B1 [Reaction:R-SSC-419166] GEFs activate RhoA,B,C
(inferredTo)	[Reaction:R-HSA-398184] LARG activation by G alpha 12/13

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