Reactome | PAK binds RAC and bPIX

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PAK binds RAC and bPIX Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10509224
displayName	PAK binds RAC and bPIX
eventOf	[Pathway:R-SSC-3928664] Ephrin signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-3928625] PAKs autophosphorylate - Sus scrofa
inferredFrom	[Reaction:R-HSA-3928641] PAK binds RAC and bPIX - Homo sapiens
input	[Complex:R-SSC-3928560] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] [CandidateSet:R-SSC-442619] PAK1/3, 2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PAK binds RAC and bPIX
output	[Complex:R-SSC-3928537] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane]
precedingEvent	[Reaction:R-SSC-3928633] bPIX exchanges GTP for GDP on RAC, activating it - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-3928641
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-3928664] Ephrin signaling
(precedingEvent)	[Reaction:R-SSC-3928625] PAKs autophosphorylate
(inferredTo)	[Reaction:R-HSA-3928641] PAK binds RAC and bPIX

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