Reactome | SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol

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SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10472614] monoamine transmembrane transporter activity of SLC6A3 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10472616
displayName	SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol
eventOf	[Pathway:R-SSC-379401] Dopamine clearance from the synaptic cleft - Sus scrofa [Pathway:R-SSC-442660] SLC-mediated transport of neurotransmitters - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-SSC-379398] Enzymatic degradation of Dopamine by monoamine oxidase - Sus scrofa [Pathway:R-SSC-379397] Enzymatic degradation of dopamine by COMT - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:171382] dopamine uptake involved in synaptic transmission
inferredFrom	[Reaction:R-HSA-379393] SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-188972] Cl- [extracellular region] [SimpleEntity:R-ALL-380873] DA [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol Reuptake of dopamine from the synaptic cleft into neurons
output	[SimpleEntity:R-ALL-352022] Cl- [cytosol] [SimpleEntity:R-ALL-159362] DA [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-379393
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-379401] Dopamine clearance from the synaptic cleft [Pathway:R-SSC-442660] SLC-mediated transport of neurotransmitters
(precedingEvent)	[Pathway:R-SSC-379398] Enzymatic degradation of Dopamine by monoamine oxidase [Pathway:R-SSC-379397] Enzymatic degradation of dopamine by COMT
(inferredTo)	[Reaction:R-HSA-379393] SLC6A3 cotransports DA, Na+, Cl- from extracellular region to cytosol

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