Reactome | Activated AKT phosphorylates AKT1S1 (PRAS40)

Schema > Reaction > Entries

Activated AKT phosphorylates AKT1S1 (PRAS40) Show undefined attributes

catalystActivity	[CatalystActivity:10458727] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category	transition
compartment	[Compartment:17938] lysosomal membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10471945
displayName	Activated AKT phosphorylates AKT1S1 (PRAS40)
eventOf	[Pathway:R-SSC-165159] MTOR signalling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5672828] mTORC1 phosphorylates AKT1S1 - Sus scrofa [Reaction:R-SSC-165692] Phosphorylation of 4E-BP1 by activated mTORC1 - Sus scrofa [Reaction:R-SSC-165718] mTORC1 phosphorylation of RPS6KB1 (S6K) - Sus scrofa
inferredFrom	[Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-5672831] mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated AKT phosphorylates AKT1S1 (PRAS40)
output	[Complex:R-SSC-165678] Active mTORC1 complex [lysosomal membrane] [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-SSC-377124] phospho-AKT1S1 [cytosol]
precedingEvent	[Reaction:R-SSC-5672843] AKT1S1 (PRAS40) binds mTORC1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-377186
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-165159] MTOR signalling
(precedingEvent)	[Reaction:R-SSC-5672828] mTORC1 phosphorylates AKT1S1 [Reaction:R-SSC-165692] Phosphorylation of 4E-BP1 by activated mTORC1 [Reaction:R-SSC-165718] mTORC1 phosphorylation of RPS6KB1 (S6K)
(inferredTo)	[Reaction:R-HSA-377186] Activated AKT phosphorylates AKT1S1 (PRAS40)