Reactome | Caspase-mediated cleavage of TJP1

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10466329] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10470541
displayName	Caspase-mediated cleavage of TJP1
eventOf	[Pathway:R-SSC-351906] Apoptotic cleavage of cell adhesion proteins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-351913] Caspase-mediated cleavage of TJP1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-3209845] TJP1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase-mediated cleavage of TJP1
output	[EntityWithAccessionedSequence:R-SSC-3209844] TJP1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-351913
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-351906] Apoptotic cleavage of cell adhesion proteins
(inferredTo)	[Reaction:R-HSA-351913] Caspase-mediated cleavage of TJP1

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