Reactome | Disassembly of SR-BI-bound spherical HDL

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Disassembly of SR-BI-bound spherical HDL Show undefined attributes

category	dissociation
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10470268
displayName	Disassembly of SR-BI-bound spherical HDL
eventOf	[Pathway:R-SSC-8964011] HDL clearance - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle - Sus scrofa
inferredFrom	[Reaction:R-HSA-349638] Disassembly of SR-BI-bound spherical HDL - Homo sapiens
input	[Complex:R-SSC-349649] spherical HDL:SR-BI complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Disassembly of SR-BI-bound spherical HDL
output	38 × [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] 156 × [SimpleEntity:R-ALL-171075] cholesterol esters [plasma membrane] 134 × [SimpleEntity:R-ALL-171142] PL [plasma membrane] 2 × [Complex:R-SSC-349645] pre-beta HDL [extracellular region] [EntityWithAccessionedSequence:R-SSC-349415] SCARB1 [plasma membrane] 20 × [SimpleEntity:R-ALL-171057] TAGs [plasma membrane]
precedingEvent	[Reaction:R-SSC-349637] spherical HDL and SR-BI receptor form a complex at the cell surface - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-349638
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8964011] HDL clearance
(precedingEvent)	[Reaction:R-SSC-349657] pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle
(inferredTo)	[Reaction:R-HSA-349638] Disassembly of SR-BI-bound spherical HDL

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