Reactome | TNF-? is cleaved by ADAM17 (TACE)

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TNF-? is cleaved by ADAM17 (TACE) Show undefined attributes

catalystActivity	[CatalystActivity:10508123] metalloendopeptidase activity of ADAM17 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10508125
displayName	TNF-? is cleaved by ADAM17 (TACE)
eventOf	[Pathway:R-SSC-75893] TNF signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Sus scrofa [Reaction:R-SSC-9714924] TNF-alpha inhibitors bind to soluble TNF trimer - Sus scrofa [Reaction:R-SSC-3371353] Soluble TNF-? binds TNFR1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-3371385] TNF-? is cleaved by ADAM17 (TACE) - Homo sapiens
input	[Complex:R-SSC-3371351] TNF(1-233) trimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF-? is cleaved by ADAM17 (TACE)
output	[Complex:R-SSC-8863104] TNF(1-76) trimer [plasma membrane] [Complex:R-SSC-3371370] TNF-? trimer, soluble form [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-3371385
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-75893] TNF signaling
(precedingEvent)	[Reaction:R-SSC-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer [Reaction:R-SSC-9714924] TNF-alpha inhibitors bind to soluble TNF trimer [Reaction:R-SSC-3371353] Soluble TNF-? binds TNFR1
(inferredTo)	[Reaction:R-HSA-3371385] TNF-? is cleaved by ADAM17 (TACE)