Reactome | IRF3-mediated induction of type I IFN

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IRF3-mediated induction of type I IFN Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557921
displayName	IRF3-mediated induction of type I IFN
eventOf	[Pathway:R-SSC-1834941] STING mediated induction of host immune responses - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259970] positive regulation of type I interferon production
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-2396002] TBK1 is phosphorylated within STING:TBK1:IRF3 complex - Sus scrofa [Reaction:R-SSC-2396007] IRF3 is phosphorylated by TBK1 - Sus scrofa [Reaction:R-SSC-2395992] p-T,4S-IRF3 is dimerized - Sus scrofa [Reaction:R-SSC-2032396] Dimerized phospho-IRF3 migrates to the nucleus - Sus scrofa
inferredFrom	[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	IRF3-mediated induction of type I IFN
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-3270619
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1834941] STING mediated induction of host immune responses
(inferredTo)	[Pathway:R-HSA-3270619] IRF3-mediated induction of type I IFN

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