Reactome | MTRR reduces cob(II)alamin to meCbl

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MTRR reduces cob(II)alamin to meCbl Show undefined attributes

catalystActivity	[CatalystActivity:10506480] [methionine synthase] reductase (NADPH) activity of MTRR:MTR:cob(II)alamin [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10506482
displayName	MTRR reduces cob(II)alamin to meCbl
eventOf	[Pathway:R-SSC-9759218] Cobalamin (Cbl) metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS - Sus scrofa
inferredFrom	[Reaction:R-HSA-3149518] MTRR reduces cob(II)alamin to meCbl - Homo sapiens
input	2 × [SimpleEntity:R-ALL-71284] AdoMet [cytosol] 2 × [Complex:R-SSC-3149544] MTRR:MTR:cob(II)alamin [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MTRR reduces cob(II)alamin to meCbl 2 (methionine synthase)-cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine => 2 (methionine synthase)-methylcob(III)alamin + H(+) + NADP(+) + 2 S-adenosyl-L-homocysteine
output	2 × [SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] 2 × [Complex:R-SSC-3149551] MTRR:MTR:MeCbl [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[BlackBoxEvent:R-SSC-3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-3149518
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-SSC-174374] MTR transfers CH3 from MeCbl to HCYS
(inferredTo)	[Reaction:R-HSA-3149518] MTRR reduces cob(II)alamin to meCbl

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