Reactome | Caspase-8 processing within TLR4 complex

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Caspase-8 processing within TLR4 complex Show undefined attributes

catalystActivity	[CatalystActivity:10504866] cysteine-type endopeptidase activity of activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
category	transition
compartment	[Compartment:74700] endosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10504868
displayName	Caspase-8 processing within TLR4 complex
eventOf	[Pathway:R-SSC-140534] Caspase activation via Death Receptors in the presence of ligand - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-350319] Caspase mediated cleavage of vimentin at IDVD (259) - Sus scrofa [Reaction:R-SSC-201637] Caspase-mediated cleavage of plectin-1 - Sus scrofa [Reaction:R-SSC-351863] Translocation of active caspase-8 to the mitochondrial membrane - Sus scrofa [BlackBoxEvent:R-SSC-9757951] CASP8 cleaves N4BP1 at D424, D490 - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
inferredFrom	[Reaction:R-HSA-2562564] Caspase-8 processing within TLR4 complex - Homo sapiens
input	[Complex:R-SSC-2562542] activated TLR4:TRIF:RIP1:FADD:pro-caspase-8 [endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Caspase-8 processing within TLR4 complex
output	[Complex:R-SSC-2562577] activated TLR4:TRIF:RIP1:FADD [endosome membrane] [Complex:R-SSC-2562550] active caspase-8 [cytosol]
precedingEvent	[Reaction:R-SSC-2562541] TLR4-induced ripoptosome assembly - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2562564
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-140534] Caspase activation via Death Receptors in the presence of ligand [Pathway:R-SSC-2562578] TRIF-mediated programmed cell death
(precedingEvent)	[Reaction:R-SSC-350319] Caspase mediated cleavage of vimentin at IDVD (259) [Reaction:R-SSC-201637] Caspase-mediated cleavage of plectin-1 [Reaction:R-SSC-351863] Translocation of active caspase-8 to the mitochondrial membrane [BlackBoxEvent:R-SSC-9757951] CASP8 cleaves N4BP1 at D424, D490
(inferredTo)	[Reaction:R-HSA-2562564] Caspase-8 processing within TLR4 complex