Reactome | Sec is reduced to H2Se by PXLP-K259-SCLY dimer

Schema > Reaction > Entries

Sec is reduced to H2Se by PXLP-K259-SCLY dimer Show undefined attributes

catalystActivity	[CatalystActivity:10503759] selenocysteine lyase activity of PXLP-K259-SCLY dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10503761
displayName	Sec is reduced to H2Se by PXLP-K259-SCLY dimer
eventOf	[Pathway:R-SSC-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8959510] SEPHS2 phosphorylates H2Se to form SELP - Sus scrofa
inferredFrom	[Reaction:R-HSA-2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer - Homo sapiens
input	[SimpleEntity:R-ALL-1131953] hydrogen donor [cytosol] [SimpleEntity:R-ALL-5357697] Sec [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Sec is reduced to H2Se by PXLP-K259-SCLY dimer AH2 + L-selenocysteine => A + H(+) + hydrogenselenide + L-alanine
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-1130886] hydrogen acceptor [cytosol] [SimpleEntity:R-ALL-29432] L-Ala [cytosol] [SimpleEntity:R-ALL-5357660] selanide [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2408524
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SSC-8959510] SEPHS2 phosphorylates H2Se to form SELP
(hasEvent)	[Pathway:R-SSC-2408508] Metabolism of ingested SeMet, Sec, MeSec into H2Se
(inferredTo)	[Reaction:R-HSA-2408524] Sec is reduced to H2Se by PXLP-K259-SCLY dimer

Cite Us!