Reactome | Dephosphorylated SMAD2/3 translocates to the cytosol

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Dephosphorylated SMAD2/3 translocates to the cytosol Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10502650
displayName	Dephosphorylated SMAD2/3 translocates to the cytosol
eventOf	[Pathway:R-SSC-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2187395] Dephosphorylated SMAD2/3 translocates to the cytosol - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-206150] SMAD3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylated SMAD2/3 translocates to the cytosol
output	[EntityWithAccessionedSequence:R-SSC-170855] SMAD3 [cytosol]
precedingEvent	[Reaction:R-SSC-209055] PPM1A dephosphorylates nuclear SMAD2/3 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2187395
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(inferredTo)	[Reaction:R-HSA-2187395] Dephosphorylated SMAD2/3 translocates to the cytosol

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