Reactome | SMAD3 binds STUB1 (CHIP)

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10502644
displayName	SMAD3 binds STUB1 (CHIP)
eventOf	[Pathway:R-SSC-2173788] Downregulation of TGF-beta receptor signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-2187368] STUB1 (CHIP) ubiquitinates SMAD3 - Sus scrofa
inferredFrom	[Reaction:R-HSA-2187375] SMAD3 binds STUB1 (CHIP) - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-170855] SMAD3 [cytosol] [EntityWithAccessionedSequence:R-SSC-975970] STUB1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SMAD3 binds STUB1 (CHIP)
output	[Complex:R-SSC-2187365] SMAD3:STUB1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2187375
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-2173788] Downregulation of TGF-beta receptor signaling
(precedingEvent)	[Reaction:R-SSC-2187368] STUB1 (CHIP) ubiquitinates SMAD3
(inferredTo)	[Reaction:R-HSA-2187375] SMAD3 binds STUB1 (CHIP)

Cite Us!