Reactome | PGE2 is converted to PGF2a by CBR1

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PGE2 is converted to PGF2a by CBR1 Show undefined attributes

catalystActivity	[CatalystActivity:10501735] prostaglandin E2 9-reductase activity of CBR1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10501737
displayName	PGE2 is converted to PGF2a by CBR1
eventOf	[Pathway:R-SSC-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2161651] PGE2 is converted to PGF2a by CBR1 - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-265287] PGE2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PGE2 is converted to PGF2a by CBR1 H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-879535] PGF2a [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2161651
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(inferredTo)	[Reaction:R-HSA-2161651] PGE2 is converted to PGF2a by CBR1

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