Reactome | PGH2 is degraded to 12S-HHT and MDA by TBXAS1

Schema > Reaction > Entries

PGH2 is degraded to 12S-HHT and MDA by TBXAS1 Show undefined attributes

catalystActivity	[CatalystActivity:10501718] 12-hydroxyheptadecatrienoic acid synthase activity of TBXAS1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10501720
displayName	PGH2 is degraded to 12S-HHT and MDA by TBXAS1
eventOf	[Pathway:R-SSC-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1 - Homo sapiens
input	[SimpleEntity:R-ALL-30138] PGH2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	PGH2 is degraded to 12S-HHT and MDA by TBXAS1 prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
output	[SimpleEntity:R-ALL-2142797] 12S-HHT [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-2161562] MDA [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-SSC-140359] PGG2 is reduced to PGH2 by PTGS1 - Sus scrofa [Reaction:R-SSC-2309773] PGG2 is reduced to PGH2 by PTGS2 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2161613
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2162123] Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
(inferredTo)	[Reaction:R-HSA-2161613] PGH2 is degraded to 12S-HHT and MDA by TBXAS1

Cite Us!