Reactome | Synthesis of 12-eicosatetraenoic acid derivatives

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Synthesis of 12-eicosatetraenoic acid derivatives Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557955
displayName	Synthesis of 12-eicosatetraenoic acid derivatives
eventOf	[Pathway:R-SSC-2142753] Arachidonate metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9980] lipoxygenase pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-2161950] Arachidonate is oxidised to 12R-HpETE by ALOX12B - Sus scrofa [Reaction:R-SSC-2161959] 12R-HpETE is reduced to 12R-HETE by GPX1/2/4 - Sus scrofa [Reaction:R-SSC-8942208] ALOXE3 isomerises 12R-HpETE to HXA3 - Sus scrofa [Reaction:R-SSC-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Sus scrofa [Reaction:R-SSC-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 - Sus scrofa [Reaction:R-SSC-2161948] Arachidonate is converted to 12-oxoETE by ALOX12 - Sus scrofa
inferredFrom	[Pathway:R-HSA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of 12-eicosatetraenoic acid derivatives
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2142712
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2142753] Arachidonate metabolism
(inferredTo)	[Pathway:R-HSA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives

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