Reactome | CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

Schema > Reaction > Entries

CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation Show undefined attributes

catalystActivity	[CatalystActivity:10469282] monooxygenase activity of Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10469284
displayName	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
eventOf	[Pathway:R-SSC-211981] Xenobiotics - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation - Homo sapiens
input	[SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211939] Phenytoin [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211927] HPHT [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-212004
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-211981] Xenobiotics
(inferredTo)	[Reaction:R-HSA-212004] CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation

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