Reactome | Methylation of N-acetyl-5-HT to form melatonin

Schema > Reaction > Entries

Methylation of N-acetyl-5-HT to form melatonin Show undefined attributes

catalystActivity	[CatalystActivity:10468646] S-methyltransferase activity of ASMT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10468648
displayName	Methylation of N-acetyl-5-HT to form melatonin
eventOf	[Pathway:R-SSC-209931] Serotonin and melatonin biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-209821] Methylation of N-acetyl-5-HT to form melatonin - Homo sapiens
input	[SimpleEntity:R-ALL-209793] Ac5HT [cytosol] [SimpleEntity:R-ALL-71284] AdoMet [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Methylation of N-acetyl-5-HT to form melatonin
output	[SimpleEntity:R-ALL-71285] AdoHcy [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-209934] MLT [cytosol]
precedingEvent	[Reaction:R-SSC-209792] N-acetylation of serotonin - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-209821
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-209931] Serotonin and melatonin biosynthesis
(inferredTo)	[Reaction:R-HSA-209821] Methylation of N-acetyl-5-HT to form melatonin

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