Reactome | Thyroxine is deiodinated to triiodothyronine

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Thyroxine is deiodinated to triiodothyronine Show undefined attributes

catalystActivity	[CatalystActivity:10468582] thyroxine 5'-deiodinase activity of DIO dimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10468584
displayName	Thyroxine is deiodinated to triiodothyronine
eventOf	[Pathway:R-SSC-350864] Regulation of thyroid hormone activity - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-209772] Thyroxine is deiodinated to triiodothyronine - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-209937] T4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Thyroxine is deiodinated to triiodothyronine
output	[SimpleEntity:R-ALL-209785] I- [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-176667] T3 [cytosol]
precedingEvent	[Reaction:R-SSC-209840] Two DITs combine to form thyroxine - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-209772
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-350864] Regulation of thyroid hormone activity
(inferredTo)	[Reaction:R-HSA-209772] Thyroxine is deiodinated to triiodothyronine

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