Reactome | RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)

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RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10499787
displayName	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
eventOf	[Pathway:R-SSC-5663213] RHO GTPases Activate WASPs and WAVEs - Sus scrofa [Pathway:R-SSC-2029482] Regulation of actin dynamics for phagocytic cup formation - Sus scrofa [Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-2130194] ABL phosphorylates WAVEs - Sus scrofa
inferredFrom	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-442574] BAIAP2 [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane] [Complex:R-SSC-442641] RAC1:GTP [plasma membrane] [Complex:R-SSC-2029154] WAVE Regulatory Complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
output	[Complex:R-SSC-2029147] WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane]
precedingEvent	[Reaction:R-SSC-5218839] DOCK180:ELMO exchanges GTP for GDP, activating RAC1 - Sus scrofa [Reaction:R-SSC-5218850] VAV exchanges GTP for GDP on RAC1, activating it - Sus scrofa [Reaction:R-SSC-8848618] Activation of RAC1 by the PXN:CRK complex - Sus scrofa [Reaction:R-SSC-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2029465
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway [Pathway:R-SSC-5663213] RHO GTPases Activate WASPs and WAVEs [Pathway:R-SSC-2029482] Regulation of actin dynamics for phagocytic cup formation
(precedingEvent)	[Reaction:R-SSC-2130194] ABL phosphorylates WAVEs
(inferredTo)	[Reaction:R-HSA-2029465] RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)