Reactome | Metabolism of Angiotensinogen to Angiotensins

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Metabolism of Angiotensinogen to Angiotensins Show undefined attributes

compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557911
displayName	Metabolism of Angiotensinogen to Angiotensins
eventOf	[Pathway:R-SSC-2980736] Peptide hormone metabolism - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Sus scrofa [Reaction:R-SSC-2022403] Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Sus scrofa [Reaction:R-SSC-2065357] Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10)) - Sus scrofa [Reaction:R-SSC-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-SSC-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-SSC-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-SSC-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-SSC-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Sus scrofa [Reaction:R-SSC-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Sus scrofa [Reaction:R-SSC-2022398] ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)) - Sus scrofa [Reaction:R-SSC-2022368] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7) - Sus scrofa [Reaction:R-SSC-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) - Sus scrofa [Reaction:R-SSC-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Sus scrofa [Reaction:R-SSC-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Sus scrofa [Reaction:R-SSC-9619024] CES1 trimer hydrolyses ACEI pro-drugs to ACEIs - Sus scrofa [Reaction:R-SSC-9614933] ACEIs bind ACE - Sus scrofa
inferredFrom	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Metabolism of Angiotensinogen to Angiotensins
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-2022377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2980736] Peptide hormone metabolism
(inferredTo)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins

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