Reactome | Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

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Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines Show undefined attributes

catalystActivity	[CatalystActivity:10497178] procollagen-lysine 5-dioxygenase activity of Lysyl hydroxylases [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10497180
displayName	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
eventOf	[Pathway:R-SSC-1650814] Collagen biosynthesis and modifying enzymes - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines - Homo sapiens
input	[SimpleEntity:R-ALL-1650779] 2OG [endoplasmic reticulum lumen] [Complex:R-SSC-2023011] Lysyl hydroxylases:Lysyl hydroxylase procollagen substrates [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines
output	[SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [Complex:R-SSC-2022428] Lysyl hydroxylases:Lysyl hydroxylated collagen propeptides [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-1650769] SUCCA [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1981104
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1650814] Collagen biosynthesis and modifying enzymes
(inferredTo)	[Reaction:R-HSA-1981104] Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines

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