Reactome | CYP21A2 21-hydroxylates PROG

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CYP21A2 21-hydroxylates PROG Show undefined attributes

catalystActivity	[CatalystActivity:10464188] progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10464190
displayName	CYP21A2 21-hydroxylates PROG
eventOf	[Pathway:R-SSC-193993] Mineralocorticoid biosynthesis - Sus scrofa [Pathway:R-SSC-211976] Endogenous sterols - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193964] CYP21A2 21-hydroxylates PROG - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-193055] P4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP21A2 21-hydroxylates PROG O2 + progesterone + reduced (NADPH--hemoprotein reductase) => 21-hydroxyprogesterone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) 21-hydroxylation of progesterone to form 11-deoxycorticosterone progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O
output	[SimpleEntity:R-ALL-194037] 11DCORST [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-193964
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-211976] Endogenous sterols [Pathway:R-SSC-193993] Mineralocorticoid biosynthesis
(inferredTo)	[Reaction:R-HSA-193964] CYP21A2 21-hydroxylates PROG

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