Reactome | NGF homodimer binds to p75NTR

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NGF homodimer binds to p75NTR Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463985
displayName	NGF homodimer binds to p75NTR
eventOf	[Pathway:R-SSC-205017] NFG and proNGF binds to p75NTR - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-193656] p75NTR interacts with RIP2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-193653] NGF homodimer binds to p75NTR - Homo sapiens
input	[Complex:R-SSC-187031] mature beta-NGF homodimer [extracellular region] [EntityWithAccessionedSequence:R-SSC-193664] NGFR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NGF homodimer binds to p75NTR
output	[Complex:R-SSC-205123] mature NGF homodimer:p75NTR [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-193653
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-SSC-193656] p75NTR interacts with RIP2
(hasEvent)	[Pathway:R-SSC-205017] NFG and proNGF binds to p75NTR
(inferredTo)	[Reaction:R-HSA-193653] NGF homodimer binds to p75NTR

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