Reactome | Cholesterol is hydroxylated to 25-hydroxycholesterol

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Cholesterol is hydroxylated to 25-hydroxycholesterol Show undefined attributes

catalystActivity	[CatalystActivity:10463652] steroid hydroxylase activity of CH25H (Fe2+ cofactor) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463654
displayName	Cholesterol is hydroxylated to 25-hydroxycholesterol
eventOf	[Pathway:R-SSC-192105] Synthesis of bile acids and bile salts - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-191983] Cholesterol is hydroxylated to 25-hydroxycholesterol - Homo sapiens
input	[SimpleEntity:R-ALL-176478] CHOL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cholesterol is hydroxylated to 25-hydroxycholesterol
output	[SimpleEntity:R-ALL-192148] 25OH-CHOL [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-191983
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-192105] Synthesis of bile acids and bile salts
(inferredTo)	[Reaction:R-HSA-191983] Cholesterol is hydroxylated to 25-hydroxycholesterol

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