Reactome | Two FAPP molecules dimerize to form presqualene diphosphate

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Two FAPP molecules dimerize to form presqualene diphosphate Show undefined attributes

catalystActivity	[CatalystActivity:10463431] squalene synthase [NAD(P)H] activity of FDFT:Mg2+ [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463435
displayName	Two FAPP molecules dimerize to form presqualene diphosphate
eventOf	[Pathway:R-SSC-9969896] Lanosterol biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate - Sus scrofa [Reaction:R-SSC-191402] Reduction of presqualene diphosphate to form squalene - Sus scrofa
inferredFrom	[Reaction:R-HSA-191405] Two FAPP molecules dimerize to form presqualene diphosphate - Homo sapiens
input	2 × [SimpleEntity:R-ALL-191385] FAPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Two FAPP molecules dimerize to form presqualene diphosphate 2 (2E,6E)-farnesyl diphosphate => presqualene diphosphate + diphosphate
output	[SimpleEntity:R-ALL-111294] PPi [cytosol] [SimpleEntity:R-ALL-191265] PSQPP [cytosol]
precedingEvent	[Reaction:R-SSC-191303] FDPS dimer transfers IPPP to GPP - Sus scrofa [Reaction:R-SSC-9717830] GGPS1 hexamer transfers IPPP to GPP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-191405
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9969896] Lanosterol biosynthesis
(precedingEvent)	[Reaction:R-SSC-8952137] Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate [Reaction:R-SSC-191402] Reduction of presqualene diphosphate to form squalene
(inferredTo)	[Reaction:R-HSA-191405] Two FAPP molecules dimerize to form presqualene diphosphate

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