Reactome | Activated TrkA receptor internalizes to endosomes

Schema > BlackBoxEvent > Entries

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10463016
displayName	Activated TrkA receptor internalizes to endosomes
eventOf	[Pathway:R-SSC-187042] TRKA activation by NGF - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-170964] FRS2 binds to active TrkA receptor - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-190065] Activated TrkA receptor internalizes to endosomes - Homo sapiens
input	[Complex:R-SSC-166540] Activated TrkA receptor complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated TrkA receptor internalizes to endosomes
output	[Complex:R-SSC-190083] Activated TrkA receptor complex [endosome membrane]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-190065
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-187042] TRKA activation by NGF
(precedingEvent)	[Reaction:R-SSC-170964] FRS2 binds to active TrkA receptor
(inferredTo)	[BlackBoxEvent:R-HSA-190065] Activated TrkA receptor internalizes to endosomes

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