Reactome | Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10462738] cyclin-dependent protein serine/threonine kinase activity of Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-SSC-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462735
displayName	Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
hasComponent	[Complex:R-SSC-141608] CCNA:CDK2 [nucleoplasm] [DefinedSet:R-SSC-182558] CDKN1A,CDKN1B [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm] - Homo sapiens
maxDepth	4
name	Cyclin A:Cdk2:p21/p27 complex
negativelyRegulates	[NegativeRegulation:10508639] Negative regulation by 'Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]'
producedByEvent	[Reaction:R-SSC-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-187926
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10508639] Negative regulation by 'Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]'
(input)	[Reaction:R-SSC-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21
(physicalEntity)	[CatalystActivity:10462738] cyclin-dependent protein serine/threonine kinase activity of Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]
(output)	[Reaction:R-SSC-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21
(inferredTo)	[Complex:R-HSA-187926] Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]

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