Reactome | Autophosphorylation of PDGF beta receptors

Schema > Reaction > Entries

Autophosphorylation of PDGF beta receptors Show undefined attributes

catalystActivity	[CatalystActivity:10462586] protein tyrosine kinase activity of PDGF beta receptor:PDGF chain B homodimer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10462588
displayName	Autophosphorylation of PDGF beta receptors
eventOf	[Pathway:R-SSC-186797] Signaling by PDGF - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Sus scrofa [Reaction:R-SSC-186778] SHP2 binds to the active receptor - Sus scrofa [Reaction:R-SSC-186798] GAP binds to PDGF-beta receptors only - Sus scrofa [Reaction:R-SSC-380782] STAT binds to the active receptor - Sus scrofa [Reaction:R-SSC-186819] SH2 domain of Src binds to the active receptor - Sus scrofa [Reaction:R-SSC-186780] PI3-kinase binds to the active receptor - Sus scrofa [Reaction:R-SSC-186765] PLC-gamma binds to the active receptor - Sus scrofa [Reaction:R-SSC-186826] GRB2:SOS1 complex binds to the active receptor - Sus scrofa [Reaction:R-SSC-382055] Grb7 binds to the active PDGF receptor - Sus scrofa [Reaction:R-SSC-382056] Crk binds to the active PDGF receptor - Sus scrofa [Reaction:R-SSC-382058] Nck binds to the active PDGF receptor - Sus scrofa
inferredFrom	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens
input	24 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-389078] PDGF beta receptor:PDGF chain B homodimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Autophosphorylation of PDGF beta receptors
output	24 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-389074] Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-186773] PDGF dimer binds two receptors simultaneously - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-186786
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-186797] Signaling by PDGF
(precedingEvent)	[Reaction:R-SSC-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 [Reaction:R-SSC-186778] SHP2 binds to the active receptor [Reaction:R-SSC-382055] Grb7 binds to the active PDGF receptor [Reaction:R-SSC-186798] GAP binds to PDGF-beta receptors only [Reaction:R-SSC-380782] STAT binds to the active receptor [Reaction:R-SSC-382056] Crk binds to the active PDGF receptor [Reaction:R-SSC-382058] Nck binds to the active PDGF receptor [Reaction:R-SSC-186819] SH2 domain of Src binds to the active receptor [Reaction:R-SSC-186780] PI3-kinase binds to the active receptor [Reaction:R-SSC-186765] PLC-gamma binds to the active receptor [Reaction:R-SSC-186826] GRB2:SOS1 complex binds to the active receptor
(inferredTo)	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors

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