Reactome | C9 binds C5b:C6:C7:C8

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C9 binds C5b:C6:C7:C8 Show undefined attributes

category	binding
compartment	[Compartment:947586] external side of plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10460984
displayName	C9 binds C5b:C6:C7:C8
eventOf	[Pathway:R-SSC-166665] Terminal pathway of complement - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-173725] C9 binds C5b:C6:C7:C8 - Homo sapiens
input	[Complex:R-SSC-173722] C5b:C6:C7:C8 [plasma membrane] 12 × [EntityWithAccessionedSequence:R-SSC-173717] C9 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	C9 binds C5b:C6:C7:C8 Creation of the Membrane Attack Complex (MAC)
output	[Complex:R-SSC-173728] Membrane Attack Complex [plasma membrane]
precedingEvent	[Reaction:R-SSC-173723] C8 binds C5b:C6:C7 - Sus scrofa
regulatedBy	[NegativeRegulation:10460974] Negative regulation by 'CLU:C5b:C6:C7, C8, C9 [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-173725
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-166665] Terminal pathway of complement
(inferredTo)	[Reaction:R-HSA-173725] C9 binds C5b:C6:C7:C8

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