Reactome | The SMAD2/3:SMAD4 complex transfers to the nucleus

Schema > BlackBoxEvent > Entries

The SMAD2/3:SMAD4 complex transfers to the nucleus Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10460208
displayName	The SMAD2/3:SMAD4 complex transfers to the nucleus
eventOf	[Pathway:R-SSC-1181150] Signaling by NODAL - Sus scrofa [Pathway:R-SSC-1502540] Signaling by Activin - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements - Sus scrofa [Reaction:R-SSC-8878143] RUNX3 binds SMAD3 and SMAD4 - Sus scrofa [Reaction:R-SSC-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer - Sus scrofa [BlackBoxEvent:R-SSC-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling - Sus scrofa [Reaction:R-SSC-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 - Sus scrofa [Reaction:R-SSC-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer - Sus scrofa [Reaction:R-SSC-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Sus scrofa [Reaction:R-SSC-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 - Sus scrofa [Reaction:R-SSC-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 - Sus scrofa [Reaction:R-SSC-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 - Sus scrofa [Reaction:R-SSC-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 - Sus scrofa [Reaction:R-SSC-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Sus scrofa [Reaction:R-SSC-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Homo sapiens
input	[Complex:R-SSC-9736931] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	The SMAD2/3:SMAD4 complex transfers to the nucleus
output	[Complex:R-SSC-8878153] p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - Sus scrofa
regulatedBy	[NegativeRegulation:10460209] Negative regulation by 'p-T,Y MAPK dimers [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-173488
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1502540] Signaling by Activin [Pathway:R-SSC-1181150] Signaling by NODAL [Pathway:R-SSC-2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
(precedingEvent)	[Reaction:R-SSC-1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Reaction:R-SSC-8878143] RUNX3 binds SMAD3 and SMAD4 [Reaction:R-SSC-2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer [BlackBoxEvent:R-SSC-173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling [Reaction:R-SSC-2187388] PPM1A protein phosphatase binds phosphorylated SMAD2/3 [Reaction:R-SSC-2187330] PARP1 binds SMAD2/3:SMAD4 heterotrimer [Reaction:R-SSC-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Reaction:R-SSC-2187309] SMAD2/3:SMAD4 heterotrimer binds SP1 [Reaction:R-SSC-9617996] FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 [Reaction:R-SSC-2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Reaction:R-SSC-2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Reaction:R-SSC-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling [Reaction:R-SSC-870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
(inferredTo)	[BlackBoxEvent:R-HSA-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus

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