Reactome | Toll Like Receptor 9 (TLR9) Cascade

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Toll Like Receptor 9 (TLR9) Cascade Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556457
displayName	Toll Like Receptor 9 (TLR9) Cascade
eventOf	[Pathway:R-SSC-168898] Toll-like Receptor Cascades - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262546] toll-like receptor 9 signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-1679589] Engulfed CpG DNA binds to endosomal full-length TLR9 - Sus scrofa [Reaction:R-SSC-1679098] Engulfed CpG DNA binds to endosomal N-ter TLR9 dimer - Sus scrofa [Reaction:R-SSC-187895] Engulfed CpG DNA binds to endosomal C-ter TLR9 - Sus scrofa [Reaction:R-SSC-9679045] C-ter TLR9 dimer binds HCQ - Sus scrofa [Reaction:R-SSC-188002] Rab5-mediated recruitment of class III PI3K to TLR9 - Sus scrofa [Pathway:R-SSC-975155] MyD88 dependent cascade initiated on endosome - Sus scrofa [Pathway:R-SSC-9860276] SLC15A4:TASL-dependent IRF5 activation - Sus scrofa
inferredFrom	[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	8
name	Toll Like Receptor 9 (TLR9) Cascade
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-168138
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-168898] Toll-like Receptor Cascades
(inferredTo)	[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade