Reactome | CHUK:IKBKB:IKBKG [cytosol]

Schema > Complex > Entries

CHUK:IKBKB:IKBKG [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-SSC-5357936] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG - Sus scrofa [Reaction:R-SSC-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 - Sus scrofa [Reaction:R-SSC-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta - Sus scrofa [Reaction:R-SSC-202500] Activation of IKK complex - Sus scrofa [Reaction:R-SSC-2730876] Phosphorylation of IKK-beta by TAK1 - Sus scrofa [Reaction:R-SSC-451561] NEMO binds polyubiquitinated IRAK1 - Sus scrofa [Reaction:R-SSC-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 - Sus scrofa [Reaction:R-SSC-9761344] USP18 binds IKBKG within IKK complex - Sus scrofa [Reaction:R-SSC-9909510] FKBP5 binds CHUK:IKBKB:IKBKG - Sus scrofa [Reaction:R-SSC-5626962] RACK1 binds IKKA:IKKB:NEMO - Sus scrofa [Reaction:R-SSC-9836500] IKK complex is activated by PKR - Sus scrofa [Reaction:R-SSC-937032] NEMO subunit of IKK complex binds to activated IRAK1 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10467076
displayName	CHUK:IKBKB:IKBKG [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-SSC-168104] CHUK [cytosol] [EntityWithAccessionedSequence:R-SSC-168114] IKBKB [cytosol] [EntityWithAccessionedSequence:R-SSC-168108] IKBKG [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol] - Homo sapiens
maxDepth	2
name	CHUK:IKBKB:IKBKG
producedByEvent	[Reaction:R-SSC-5609665] CHUK, IKBKB and IKBKG form IKK complex - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-168113
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-SSC-9909510] FKBP5 binds CHUK:IKBKB:IKBKG [Reaction:R-SSC-5357776] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG [Reaction:R-SSC-5626962] RACK1 binds IKKA:IKKB:NEMO [Reaction:R-SSC-975119] NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9 [Reaction:R-SSC-9836500] IKK complex is activated by PKR [Reaction:R-SSC-5607742] K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta [Reaction:R-SSC-202500] Activation of IKK complex [Reaction:R-SSC-2730876] Phosphorylation of IKK-beta by TAK1 [Reaction:R-SSC-451561] NEMO binds polyubiquitinated IRAK1 [Reaction:R-SSC-937029] IKBKG subunit of IKK complex binds polyubiquinated RIP1 [Reaction:R-SSC-9761344] USP18 binds IKBKG within IKK complex [Reaction:R-SSC-937032] NEMO subunit of IKK complex binds to activated IRAK1
(hasComponent)	[Complex:R-SSC-5357936] TNF?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] [Complex:R-SSC-5626968] IKKA:IKKB:NEMO:RACK1 [cytosol] [Complex:R-SSC-975121] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [endosome membrane] [Complex:R-SSC-451560] Poly-K6-Ub-hp-IRAK1:CHUK:IKBKB:IKBKG [cytosol] [Complex:R-SSC-937030] CHUK:IKBKB:IKBKG:K63pUb-RIP1:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] [Complex:R-SSC-9761338] CHUK:IKBKB:IKBKG:USP18 [cytosol] [Complex:R-SSC-937038] TRAF6:K63-linked polyUb p-IRAK1:IKK complex [cytosol]
(output)	[Reaction:R-SSC-5609665] CHUK, IKBKB and IKBKG form IKK complex
(inferredTo)	[Complex:R-HSA-168113] CHUK:IKBKB:IKBKG [cytosol]

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