Reactome | PRLR ligands:PRLR:JAK2 dimer [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-SSC-1675475] PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] - Sus scrofa
consumedByEvent	[BlackBoxEvent:R-SSC-1370505] PRLR is phosphorylated at Ser-349 - Sus scrofa [BlackBoxEvent:R-SSC-982810] JAK2 phosphorylation - Sus scrofa [BlackBoxEvent:R-SSC-1671687] PRLR activation - Sus scrofa [Reaction:R-SSC-1675473] SH2B binds JAK2 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10486359
displayName	PRLR ligands:PRLR:JAK2 dimer [plasma membrane]
hasComponent	[Complex:R-SSC-1364076] PRLR:JAK2 dimer [plasma membrane] [DefinedSet:R-SSC-1172021] Prolactin receptor ligands [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane] - Homo sapiens [DefinedSet:R-HSA-1364055] Activated cytokine-like hormone receptors [plasma membrane] - Homo sapiens [Complex:R-HSA-976956] PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] - Homo sapiens
maxDepth	5
name	PRLR ligands:PRLR:JAK2 dimer
producedByEvent	[BlackBoxEvent:R-SSC-1671687] PRLR activation - Sus scrofa [Reaction:R-SSC-976991] Prolactin receptor ligands bind the prolactin receptor - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-1671652
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-SSC-1370505] PRLR is phosphorylated at Ser-349 [Reaction:R-SSC-1675473] SH2B binds JAK2 [BlackBoxEvent:R-SSC-982810] JAK2 phosphorylation [BlackBoxEvent:R-SSC-1671687] PRLR activation
(output)	[BlackBoxEvent:R-SSC-1671687] PRLR activation [Reaction:R-SSC-976991] Prolactin receptor ligands bind the prolactin receptor
(inferredTo)	[Complex:R-HSA-1671652] PRLR ligands:PRLR:JAK2 dimer [plasma membrane] [DefinedSet:R-HSA-1364055] Activated cytokine-like hormone receptors [plasma membrane] [Complex:R-HSA-976956] PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane]
(hasComponent)	[Complex:R-SSC-1675475] PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane]