Reactome | OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol

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OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10458707] carnitine transmembrane transporter activity of SLC22A5 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10458709
displayName	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol
eventOf	[Pathway:R-SSC-200425] Carnitine shuttle - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:5263434] carnitine transmembrane transport
inferredFrom	[Reaction:R-HSA-165026] OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-164988] CAR [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol (R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in) carnitine [extracellular] + Na+ [extracellular] -> carnitine [cytosol] + Na+ [cytosol]
output	[SimpleEntity:R-ALL-30235] CAR [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-165026
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-200425] Carnitine shuttle
(inferredTo)	[Reaction:R-HSA-165026] OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol

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