Reactome | Synthesis of PC

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Synthesis of PC Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557007
displayName	Synthesis of PC
eventOf	[Pathway:R-SSC-1483206] Glycerophospholipid biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20466] phosphatidylcholine biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-1483174] PE is methylated to PC by PEMT - Sus scrofa [Reaction:R-SSC-8873794] PCTP binds PC - Sus scrofa [Reaction:R-SSC-9956308] STARD7 transports PC from ER membrane to mitochondrial outer membrane - Sus scrofa [Reaction:R-SSC-8873923] STARD10 binds LPCAT1 and PC - Sus scrofa [Reaction:R-SSC-8873834] STARD10 transports PC from ER membrane to lamellar body membrane - Sus scrofa [Reaction:R-SSC-8873929] Casein kinase II phosphorylates STARD10 - Sus scrofa [Reaction:R-SSC-444433] Cho transports from the extracellular space to the cytosol - Sus scrofa [Reaction:R-SSC-1483004] Cho is phosphorylated to PCho by CHK dimer - Sus scrofa [Reaction:R-SSC-1483159] PCho is dephosphorylated to Cho by PHOSPHO1 - Sus scrofa [Reaction:R-SSC-264622] Cho is acetylated to AcCho by CHAT - Sus scrofa [Reaction:R-SSC-1483081] PCho and CTP are condensed to CDP-Cho by PCYT1 dimer - Sus scrofa [Reaction:R-SSC-1483203] PA is dephosphorylated to DAG by LPIN - Sus scrofa [Reaction:R-SSC-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Sus scrofa [Reaction:R-SSC-1482973] CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane - Sus scrofa [Reaction:R-SSC-5694485] ABHD3 hydrolyses LPC(14:0) to 1AGPC - Sus scrofa [Reaction:R-SSC-8865637] MFSD2A transports LPC from extracellular region to plasma membrane - Sus scrofa
inferredFrom	[Pathway:R-HSA-1483191] Synthesis of PC - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of PC
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-1483191
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1483206] Glycerophospholipid biosynthesis
(inferredTo)	[Pathway:R-HSA-1483191] Synthesis of PC

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