Reactome | PC is hydrolysed to 2-acyl LPC by PLA2[7]

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PC is hydrolysed to 2-acyl LPC by PLA2[7] Show undefined attributes

catalystActivity	[CatalystActivity:10492656] glycerophospholipid phospholipase A1 activity of PLA2(7) [cytosol]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10492658
displayName	PC is hydrolysed to 2-acyl LPC by PLA2[7]
eventOf	[Pathway:R-SSC-1482788] Acyl chain remodelling of PC - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] - Sus scrofa [Reaction:R-SSC-1482533] 2-acyl LPC is acylated to PC by LPCAT - Sus scrofa
inferredFrom	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7] - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-426925] PC [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PC is hydrolysed to 2-acyl LPC by PLA2[7]
output	[SimpleEntity:R-ALL-975614] 2-acyl LPC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-1524021] LCFA(-) [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SSC-1482533] 2-acyl LPC is acylated to PC by LPCAT - Sus scrofa [Reaction:R-SSC-1483219] PC is exchanged with PI by PITPNB - Sus scrofa [Reaction:R-SSC-1482961] CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane - Sus scrofa [Reaction:R-SSC-1482547] 1-acyl LPC is acylated to PC by LPCAT - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1482862
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1482788] Acyl chain remodelling of PC
(precedingEvent)	[Reaction:R-SSC-1482612] 2-acyl LPC is hydrolyzed to GPCho by PLA2[8] [Reaction:R-SSC-1482533] 2-acyl LPC is acylated to PC by LPCAT
(inferredTo)	[Reaction:R-HSA-1482862] PC is hydrolysed to 2-acyl LPC by PLA2[7]