Reactome | PTPS is phosphorylated by cGMP-dependant protein kinase II

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PTPS is phosphorylated by cGMP-dependant protein kinase II Show undefined attributes

catalystActivity	[CatalystActivity:10492405] cGMP-dependent protein kinase activity of PRKG2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10492407
displayName	PTPS is phosphorylated by cGMP-dependant protein kinase II
eventOf	[Pathway:R-SSC-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-1474184] DHNTP is dephosphorylated by PTPS to PTHP - Sus scrofa
inferredFrom	[Reaction:R-HSA-1475422] PTPS is phosphorylated by cGMP-dependant protein kinase II - Homo sapiens
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-1497879] PTPS hexamer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTPS is phosphorylated by cGMP-dependant protein kinase II
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-1475058] p-PTPS hexamer [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1475422
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1474151] Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
(precedingEvent)	[Reaction:R-SSC-1474184] DHNTP is dephosphorylated by PTPS to PTHP
(inferredTo)	[Reaction:R-HSA-1475422] PTPS is phosphorylated by cGMP-dependant protein kinase II

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