Reactome | PRLR:JAK2 dimerizes

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10491026
displayName	PRLR:JAK2 dimerizes
eventOf	[Pathway:R-SSC-1170546] Prolactin receptor signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-976991] Prolactin receptor ligands bind the prolactin receptor - Sus scrofa
inferredFrom	[Reaction:R-HSA-1364044] PRLR:JAK2 dimerizes - Homo sapiens
input	2 × [Complex:R-SSC-1302663] PRLR:JAK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PRLR:JAK2 dimerizes
output	[Complex:R-SSC-1364076] PRLR:JAK2 dimer [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-1364044
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-1170546] Prolactin receptor signaling
(precedingEvent)	[Reaction:R-SSC-976991] Prolactin receptor ligands bind the prolactin receptor
(inferredTo)	[Reaction:R-HSA-1364044] PRLR:JAK2 dimerizes

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