Reactome | PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine

Schema > Reaction > Entries

PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine Show undefined attributes

catalystActivity	[CatalystActivity:10454691] A2-type glycerophospholipase activity of Active PLA2:phosphatidylcholine [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10454693
displayName	PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine
eventOf	[Pathway:R-SSC-2142753] Arachidonate metabolism - Sus scrofa [Pathway:R-SSC-111995] phospho-PLA2 pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9915992] Arachidonate is hydroxylated to 17-HETE by CYP(1) - Sus scrofa [Reaction:R-SSC-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1) - Sus scrofa [Reaction:R-SSC-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) - Sus scrofa [Reaction:R-SSC-2161940] Arachidonate is hydroxylated to 20-HETE by CYP(3) - Sus scrofa [Reaction:R-SSC-2161795] Arachidonate is hydroxylated to 16-HETE by CYP(1) - Sus scrofa [Reaction:R-SSC-2309787] Arachidonate is oxidised to PGG2 by PTGS2 - Sus scrofa [Reaction:R-SSC-140355] Arachidonate is oxidised to PGG2 by PTGS1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine - Homo sapiens
input	[SimpleEntity:R-ALL-9915525] AA-PC [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O => (5Z,8Z,11Z,14Z)-eicosatetraenoate + a 1-acyl-sn-glycero-3-phosphocholine + H+
output	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-6814253] LysoPtdCho [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-SSC-111881] Phospho-cPLA2 translocates to membranes when intracellular calcium levels increase - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-111883
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-2142753] Arachidonate metabolism [Pathway:R-SSC-111995] phospho-PLA2 pathway
(precedingEvent)	[Reaction:R-SSC-9915992] Arachidonate is hydroxylated to 17-HETE by CYP(1) [Reaction:R-SSC-9915993] Arachidonate is hydroxylated to 18-HETE by CYP(1) [Reaction:R-SSC-2161814] Arachidonate is hydroxylated to 19-HETE by CYP(2) [Reaction:R-SSC-2161940] Arachidonate is hydroxylated to 20-HETE by CYP(3) [Reaction:R-SSC-2161795] Arachidonate is hydroxylated to 16-HETE by CYP(1) [Reaction:R-SSC-2309787] Arachidonate is oxidised to PGG2 by PTGS2 [Reaction:R-SSC-140355] Arachidonate is oxidised to PGG2 by PTGS1
(inferredTo)	[Reaction:R-HSA-111883] PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine