Reactome | IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

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IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] Show undefined attributes

catalystActivity	[CatalystActivity:10454597] adenylosuccinate synthase activity of ADSS, ADSSL1 dimers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10454599
displayName	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
eventOf	[Pathway:R-SSC-73817] Purine ribonucleoside monophosphate biosynthesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate - Sus scrofa
inferredFrom	[Reaction:R-HSA-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-29448] L-Asp [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] IMP + L-aspartate + GTP => N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+) inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
output	[SimpleEntity:R-ALL-35141] ADS [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SSC-73797] FAICAR => IMP + H2O - Sus scrofa
regulatedBy	[NegativeRegulation:R-MMU-111520] Negative regulation by 'ADS [cytosol]' [NegativeRegulation:R-MMU-111521] Negative regulation by 'guanosine 5'-monophosphate [cytosol]' [NegativeRegulation:R-MMU-111522] Negative regulation by 'GDP [cytosol]' [NegativeRegulation:R-MMU-111523] Negative regulation by 'D-Fructose 1,6-bisphosphate [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-111524
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-73817] Purine ribonucleoside monophosphate biosynthesis
(precedingEvent)	[Reaction:R-SSC-73828] adenylosuccinate => adenosine 5'-monophosphate + fumarate
(inferredTo)	[Reaction:R-HSA-111524] IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]

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