Reactome | Resolution of AP sites via the single-nucleotide replacement pathway

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Resolution of AP sites via the single-nucleotide replacement pathway Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555811
displayName	Resolution of AP sites via the single-nucleotide replacement pathway
eventOf	[Pathway:R-SSC-73933] Resolution of Abasic Sites (AP sites) - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:17139] base-excision repair, gap-filling
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-SSC-73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway - Sus scrofa [Reaction:R-SSC-110376] Recruitment of LIG3:XRCC1 complex to the site of repair by POLB - Sus scrofa [Reaction:R-SSC-73932] Resynthesis of excised residue by POLB - Sus scrofa [Reaction:R-SSC-73931] LIG3-mediated DNA ligation via the single-nucleotide replacement pathway - Sus scrofa
inferredFrom	[Pathway:R-HSA-110381] Resolution of AP sites via the single-nucleotide replacement pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Resolution of AP sites via the single-nucleotide replacement pathway
precedingEvent	[Pathway:R-SSC-73927] Depurination - Sus scrofa [Pathway:R-SSC-73928] Depyrimidination - Sus scrofa
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-110381
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-73933] Resolution of Abasic Sites (AP sites)
(inferredTo)	[Pathway:R-HSA-110381] Resolution of AP sites via the single-nucleotide replacement pathway

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