Reactome | Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break

Schema > Reaction > Entries

Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break Show undefined attributes

catalystActivity	[CatalystActivity:10454538] DNA-(apurinic or apyrimidinic site) endonuclease activity of POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10454540
displayName	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
eventOf	[Pathway:R-SSC-73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-110376] Recruitment of LIG3:XRCC1 complex to the site of repair by POLB - Sus scrofa
inferredFrom	[Reaction:R-HSA-110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break - Homo sapiens
input	[Complex:R-SSC-110335] POLB:APEX1:SSB(AP->5'-dRP)-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break
output	[EntityWithAccessionedSequence:R-SSC-50119] APEX1 [nucleoplasm] [Complex:R-SSC-110337] POLB:SSB-gap-dsDNA [nucleoplasm] [SimpleEntity:R-ALL-30977] SUGP [nucleoplasm]
precedingEvent	[Reaction:R-SSC-110360] Recruitment of POLB to the AP site - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-110375
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
(precedingEvent)	[Reaction:R-SSC-110376] Recruitment of LIG3:XRCC1 complex to the site of repair by POLB
(inferredTo)	[Reaction:R-HSA-110375] Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break

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