Reactome | POLB-Dependent Long Patch Base Excision Repair

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POLB-Dependent Long Patch Base Excision Repair Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558295
displayName	POLB-Dependent Long Patch Base Excision Repair
eventOf	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Sus scrofa [Reaction:R-SSC-5649883] POLB-mediated DNA strand displacement synthesis - Sus scrofa [Reaction:R-SSC-5651723] PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate - Sus scrofa [Reaction:R-SSC-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB - Sus scrofa [Reaction:R-SSC-5651828] PARG dePARylates PARP1,PARP2 - Sus scrofa [Reaction:R-SSC-5651773] LIG1 binds POLB at long-patch BER site - Sus scrofa [Reaction:R-SSC-5651789] LIG1 bound to POLB ligates SSB - Sus scrofa [Depolymerisation:R-SSC-8952903] ADPRHL2 hydrolyses poly(ADP-ribose) - Sus scrofa
inferredFrom	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	POLB-Dependent Long Patch Base Excision Repair
precedingEvent	[Pathway:R-SSC-73927] Depurination - Sus scrofa [Pathway:R-SSC-73928] Depyrimidination - Sus scrofa
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-110362
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway
(inferredTo)	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair