Reactome | POLZ extends translesion synthesis

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POLZ extends translesion synthesis Show undefined attributes

catalystActivity	[CatalystActivity:10454440] DNA-directed DNA polymerase activity of POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10454442
displayName	POLZ extends translesion synthesis
eventOf	[Pathway:R-SSC-110312] Translesion synthesis by REV1 - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5653756] TRIM25 binds monoUb:164-PCNA - Sus scrofa [Pathway:R-SSC-5656169] Termination of translesion DNA synthesis - Sus scrofa
inferredFrom	[Reaction:R-HSA-110311] POLZ extends translesion synthesis - Homo sapiens
input	10 × [SimpleEntity:R-ALL-30555] dNTP [nucleoplasm] [Complex:R-SSC-5652152] POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLZ extends translesion synthesis
output	[Complex:R-SSC-110279] POLZ [nucleoplasm] 10 × [SimpleEntity:R-ALL-113541] PPi [nucleoplasm] [Complex:R-SSC-5652153] REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt-mispairedPolydNMP)-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5652151] REV1 recruits POLZ to (AP:Cyt)-DNA Template - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-110311
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-SSC-5656169] Termination of translesion DNA synthesis [Reaction:R-SSC-5653756] TRIM25 binds monoUb:164-PCNA
(hasEvent)	[Pathway:R-SSC-110312] Translesion synthesis by REV1
(inferredTo)	[Reaction:R-HSA-110311] POLZ extends translesion synthesis