Reactome | p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179

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p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 Show undefined attributes

catalystActivity	[CatalystActivity:11077408] protein serine kinase activity of p-T816-PKN2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11077410
displayName	p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179
eventOf	[Pathway:R-SPO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9860808] p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SPO-203564] p-S1177-eNOS dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SPO-9860769] p-S1177,S1179-eNOS dimer [plasma membrane]
precedingEvent	[Reaction:R-SPO-9860785] PDPK1 (PDK1) phosphorylates PKN2 on threonine-816 - Schizosaccharomyces pombe [Reaction:R-SPO-9860792] Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177 - Schizosaccharomyces pombe
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-9860808
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-9856530] High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
(inferredTo)	[Reaction:R-HSA-9860808] p-T816-PKN2 phosphorylates NOS3 (eNOS) on serine-1179

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